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Buy Tesamorelin

What is Tesamorelin?

Tesamorelin is a synthetic peptide designed to stimulate the natural production of growth hormone-releasing hormone (GHRH). Primarily used in the management of lipodystrophy associated with HIV, it reduces excess visceral fat accumulation, improving body composition and metabolic health. By specifically targeting fat deposits around vital organs, Tesamorelin promotes a leaner physique without significantly affecting subcutaneous fat.

Its precise mechanism of action involves binding to GHRH receptors, enhancing endogenous growth hormone levels, which then regulate fat metabolism. Clinically effective and well-tolerated when prescribed by healthcare professionals, Tesamorelin supports improved energy regulation and physical health, offering a specialised solution for individuals requiring targeted hormonal intervention [1].

Molecular Formula: C221H366N72O67S

Amino Acid Sequence: Unk-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu- Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg- Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2

Source: PubChem

Tesamorelin Structure OCEANIA from PharmaLabGlobal

Molecular Weight: 5136 g/mol

View the Tesamorelin HPLC Certificate here.

Buy Tesamorelin-Peptide-Vial OCEANIA from PharmaLabGlobal

Tesamorelin Benefits:

  • In vitro testing has established that Tesamorelin could have the following benefits:
  • Reduces visceral fat specifically around internal organs, promoting a healthier body composition.
  • Enhances metabolic health by improving lipid profiles and insulin sensitivity.
  • Supports natural growth hormone regulation by stimulating the body’s own production of growth hormone-releasing hormone (GHRH).
  • Specialised for lipodystrophy management, effectively addressing the unique needs of individuals with this condition.

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Tesamorelin is available in 2mg, 5mg or 10mg peptide vials.

Peptides supplied in sterile vials require peptide reconstitution using Bacteriostatic Water – find the full range of peptide supplies here.

Mechanism of Action of Tesamorelin

Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH), designed to mimic its natural function in the body. It binds specifically to GHRH receptors located in the anterior pituitary gland, activating these receptors to stimulate the secretion of endogenous growth hormone. This increase in growth hormone triggers a cascade of metabolic processes.

The elevated growth hormone levels enhance the breakdown of triglycerides in visceral adipose tissue, particularly visceral fat stored around internal organs. Simultaneously, Tesamorelin promotes the release of insulin-like growth factor-1 (IGF-1), which plays a critical role in mediating anabolic effects and regulating fat metabolism.

By directly targeting abnormal fat deposits, OCEANIA studies have shown that Tesamorelin improves body composition without significantly affecting subcutaneous fat [2]. Additionally, its influence on lipid metabolism helps improve insulin sensitivity and overall metabolic health. This precise mechanism underpins Tesamorelin’s clinical use in managing conditions like lipodystrophy, offering targeted benefits while utilizing the body’s natural endocrine pathways.

Tesamorelin is available in easy to use peptide nasal sprays.

Buy Tesamorelin OCEANIA from the Pharma Lab Global Website for laboratory purposes.

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Clinical Applications of Tesamorelin OCEANIA

Tesamorelin is a highly researched peptide, findings to these clinical studies have found that Tesamorelin can have the following applications:

Reduction of Visceral Fat

Tesamorelin reduces visceral fat through its targeted mechanism of action, which begins by mimicking growth hormone-releasing hormone (GHRH). It binds to GHRH receptors in the pituitary gland, stimulating the production of growth hormone. Elevated growth hormone production promotes the breakdown of triglycerides, specifically in visceral fat stored around vital organs [3].

By targeting visceral fat rather than subcutaneous fat, Tesamorelin addresses a key factor in poor metabolic health. Excess visceral fat is linked to serious conditions such as cardiovascular disease, type 2 diabetes, and systemic inflammation. Reducing body fat improves insulin sensitivity and lipid metabolism, helping to regulate blood sugar levels and minimise health risks.

The overall effect of Tesamorelin peptide therapy is weight loss and a healthier body composition, improved metabolic markers, and enhanced energy levels. This reduction in visceral obesity not only supports physical well-being but also lowers the risk of chronic conditions, contributing to long-term health and vitality.

Improves Metabolic Health and Insulin Sensivity

Tesamorelin improves metabolic health and insulin sensitivity by addressing several key mechanisms within the body. First, it reduces visceral fat, which is closely linked to metabolic dysfunction.  The targeted fat reduction caused by Tesamorelin eases the strain on internal organs and reduces inflammation, both of which are critical for metabolic health.

Tesamorelin also boosts insulin-like growth factor-1 (IGF-1) levels, which plays a vital role in regulating glucose metabolism and fat storage. By increasing IGF-1, the peptide helps improve insulin sensitivity, enabling the body to more effectively regulate blood sugar levels. Enhanced lipid metabolism further supports a healthier balance of cholesterol and triglycerides, reducing the risk of cardiovascular issues [4].

Together, these effects create a ripple of health benefits, including better blood sugar control, reduced risk of metabolic disorders, and improved energy regulation. Tesamorelin’s ability to harness these mechanisms makes it a powerful tool for enhancing overall metabolic function.

Enhances the Stimulation of Growth Hormone Levels

By precisely targeting the GHRH receptors, Tesamorelin ensures an efficient and natural elevation of growth hormone levels. Once human growth hormone is released into the bloodstream, it begins to regulate several critical processes in the body, including fat metabolism, muscle growth, and energy utilisation. This increase in growth hormone also promotes the production of insulin-like growth factor-1 (IGF-1), which supports anabolic effects and further enhances metabolic functions [5].

Helps with the Management of Lipodystrophy

Tesamorelin plays a pivotal role in managing lipodystrophy, particularly in individuals with HIV-associated lipodystrophy, a condition characterised by abnormal fat accumulation. By targeting visceral fat, Tesamorelin delivers specific and measurable benefits [6].

Elevated growth hormone levels stimulate the breakdown of excess visceral fat, which is often resistant to standard weight-loss strategies. This focused fat reduction is especially impactful around internal organs, a key concern in lipodystrophy.

Additionally, Tesamorelin promotes a healthier overall body composition. By minimising fat accumulation and improving metabolic markers, it helps patients feel more energised and supports better long-term health. These targeted benefits make Tesamorelin an effective tool for those navigating the challenges of lipodystrophy.

Tesamorelin is available from PharmaLabGlobal in Pre-Mixed Pen Kits.

Buy Tesamorelin OCEANIA Pre-Mixed Peptide for laboratory research use.

Buy Tesamorelin Ipamorelin CJC-1295 DAC OCEANIA Peptide Combo from PharmaLabGlobal

Buy Tesamorelin CJC-1295 DAC Ipamorelin Peptide Combo

Combining Tesamorelin, CJC-1295 DAC, and Ipamorelin peptides offers a synergistic approach to amplifying health and wellness. Tesamorelin stimulates growth hormone release by targeting growth hormone-releasing hormone receptors, effectively reducing visceral fat and improving metabolic health. CJC-1295 DAC, a long-acting growth hormone-releasing hormone analogue, maintains steady growth hormone and insulin-like growth factor-1 levels, supporting muscle growth and fat metabolism. Ipamorelin complements these by enhancing natural growth hormone secretion without excessive cortisol release, promoting recovery and lean muscle development.

Together, these peptides optimise fat reduction, muscle growth, and improved hormonal balance, creating a powerful combination for overall health enhancement and vitality.

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Tesamorelin FAQ’s

Does Tesamorelin have FDA approval?

Yes, Tesamorelin is FDA-approved. It was approved in 2010 for the treatment of HIV-associated lipodystrophy, a condition characterized by abnormal fat distribution in individuals living with HIV. The approval is specifically for reducing excess abdominal fat in these patients by medical professionals. However, its use is limited to this indication and is not approved for general weight loss or other conditions.

What are the side effects of Tesamorelin?

Tesamorelin, like any medication, can cause side effects. One of the most common issues is Tesamorelin injection site reactions, which may include redness, pain, or irritation where the medication is administered. Additionally, some individuals may experience muscle and joint pain, often accompanied by stiffness or discomfort.

Swelling due to fluid retention is another potential side effect, particularly in the hands, feet, or ankles. Nausea and mild to moderate headaches are also frequently reported. For some, Tesamorelin can increase blood sugar levels, which may worsen pre-existing diabetes or, in rare cases, trigger new-onset diabetes.

Tesamorelin Pre-Mixed Pen 2mg

Scientific Research

[1] Rahman F, McLaughlin T, Mesquita P, Morin J, Potvin D, De Chantal M, Aberg JA. Effect of tesamorelin in people with HIV with and without dorsocervical fat: Post hoc analysis of phase III double-blind placebo-controlled trial. J Clin Transl Sci. 2022 Dec 7;7(1):e40.

[2] Kopchick JJ, Berryman DE, Puri V, Lee KY, Jorgensen JOL. The effects of growth hormone on adipose tissue: old observations, new mechanisms. Nat Rev Endocrinol. 2020 Mar;16(3):135-146. 

[3] Stanley TL, Feldpausch MN, Oh J, Branch KL, Lee H, Torriani M, Grinspoon SK. Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial. JAMA. 2014 Jul 23-30;312(4):380-9.

[4] Clemmons DR, Miller S, Mamputu JC. Safety and metabolic effects of tesamorelin, a growth hormone-releasing factor analogue, in patients with type 2 diabetes: A randomized, placebo-controlled trial. PLoS One. 2017 Jun 15;12(6):e0179538. 

[5] Anderson LJ, Tamayose JM, Garcia JM. Use of growth hormone, IGF-I, and insulin for anabolic purpose: Pharmacological basis, methods of detection, and adverse effects. Mol Cell Endocrinol. 2018 Mar 15;464:65-74.

[6] Dhillon S. Spotlight on tesamorelin in HIV-associated lipodystrophy. BioDrugs. 2011 Dec 1;25(6):405-8.

Further Reading:

Buy Fat burning Ipamorelin and Tesamorelin from PharmaLabGlobal

Enhanced Fat Burning with Ipamorelin and Tesamorelin for Effective Fat Loss

The blog explores the synergistic benefits of combining Ipamorelin and Tesamorelin peptides for fat loss and metabolic health. It highlights their roles in stimulating growth hormone release, with Ipamorelin promoting controlled GH secretion for fat oxidation and muscle preservation, while Tesamorelin targets visceral fat reduction, particularly in the abdominal area. The article also discusses the peptides’ potential to improve body composition, regulate blood sugar, and enhance overall metabolic function. Additionally, it touches on related peptides like Hexarelin and the Tesamorelin-Sermorelin stack, emphasizing their combined effects on fat metabolism and muscle maintenance, making them promising tools in fat loss research.

Read about this peptide combination

Increasing Growth Hormones with Peptides PharmaLabGlobal

Increasing Growth Hormones with Peptides

This article delves into the synergistic effects of combining Sermorelin and GHRP-6 peptides to enhance growth hormone secretion. Sermorelin, a synthetic Growth Hormone-Releasing Hormone (GHRH), and GHRP-6, a Growth Hormone-Releasing Peptide, work together to stimulate the pituitary gland, resulting in a robust and sustained release of growth hormone. This combination is studied for its potential to improve muscle regeneration, fat metabolism, and overall metabolic health. The article also highlights the importance of peptide stacks in research, emphasizing their role in advancing treatments for growth hormone deficiencies, metabolic disorders, and age-related health challenges.

Discover growth hormone peptides

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Can Sermorelin and Tesamorelin Improve Sleep? Research on Peptides for Better Sleep Quality

Explore the potential of Tesamorelin and Sermorelin peptides in improving sleep quality through their influence on growth hormone (GH) levels. It highlights how GH, primarily released during deep sleep, supports restorative processes like cellular repair and muscle recovery. Sermorelin stimulates natural GH production, enhancing deep sleep and recovery, while Tesamorelin optimizes sleep efficiency by stabilizing circadian rhythms and promoting REM sleep. The article also discusses related peptides like DSIP and Epithalon, which regulate sleep-wake cycles and melatonin production. While promising for sleep research, these peptides are strictly for research purposes, with further studies needed to confirm their effects.

Check out the full blog here.

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